haemostasis:-
- stoppage of bleeding/arrest of bleeding
- steps
- vasoconstriction -because of release of serotonin
- platelet plug fornation
- blood coagulatin
- blood in circulation do not clot
- natural anticoagulant heparin -keeps fluid condition
- intact endothelium of blood vesels
- coagulation factors are all in inactive forms in circulation but active form whenever blood exposed
- velocity of blood
- blood coagulation:-
- physiological complex process where in fluidity of the blood is lost and becomes jelly like or semi solid and there by reduces the blood loss from the injured vessel
- steps-
- formation of prothrombin activator
- intrinsic
- extrinsic
- conversion of prothrombin to thrombin
- fibrinogen to fibrin
- coagulation factors-
- i)fibrinogen-plasma protein
- ii)prothrombin
- iii)thromboplastin
- iv)calcium
- v)proaccelerin
- vii)proconverting-triggering factor for extrinsic mechanism of blood coagulation
- viii)anti hemophilic factor
- ix)christmas factor
- x)stuart power factor
- xi)plasma thromboplastin
- xii)Hagemans factor
- xiii)fibrin stabilising factor
- methods of blood coagulation:-####
- anticoagulants:-chemical substance that prevent coagulation
- invitro eg:-heparin,citrates,oxalates
- invivo eg:- warfarin
- heparin :-naturally occuring anti coagulant
- synthesized from hepatocytes of liver
- prevent blood coagulation
- heparin can be used in both vivo and vitro
- uses of anticoagulants:-
- blood bank,in lab investigation,incase of renal failure,incase of open heart surgery
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