Co2 transport:-
Co2 metabolic waste from tissue to lung its travel
Pco2 in tissue level -collected inside the tissue level-46mmhg
Inside the capillaries -lesser ie,46mmhg
Inside the alveoli 40mmhg
Co2 content in venous blood volume contains 52%
Co2 content in arterial blood contain 48%
Method of c02:-
1)physiological solution:-in plasma 7%of total co2 due to absence of carbonic anhydrase in plasma
2) with protein-forms carbamino compound
2 protein- -hb ,plasma protein
-hb/plasma protein +co2 carbonic acid
23%of co2 is transported
3)as bicarbonates-70% of co2is transported occurs at lung level
Chloride shift:-###
The co2 inside the RBC forms h2co3 carbonic anhydrase
-the carbonic acid dissociate into H+ and bicarbonate ions
The excess of bicarbonate ions shift to the plasma
-to maintain the electrolyte balance chloride ions from plasma shif into the RBC known as chloride shift.
Lung level:-
Haldines effect-
Reversal of process occurs ,Hb dissociation into H+and Hb
NAHCO3 DISSOCIATE IN NA and hco3-
###
Greater the concentration 0f 02 more will be tthe dissociation of CO2
Compliance:-
It is the stretchability of lung tissue
-it is one of the lung function test
compliance=delta vol/delta pressure =200ml/1cm of h20
Compliance at rest it is straight line and during inspiraton and expirationit doesnt overlap
-it shows hysteries loop.
Factors affecting:-
1)surfactant -reduced causes respiratory distress and compliance is reduced
2)muscle power of respiratory muscles weak -compliance is reduced
Eg:poliomyleities
3)fibrosis of alveoi-compliance is reduces
Eg:-emphysem,tuberculosis
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