RBC:-
i)nonucleated,non cell division.
ii)life span-120 days
iii)perish and accumulate in spleen
iv)no mitochondria
v)it is biconcave shaped to facilitate diffusion
it increases surface area for diffusion
diameter -7.2 micron
thjickness-1.1 micron
mean corpuscular volume - 80-90micro cube
normal count-male :-5-5.5 million mm3
female -4.5-- 5 million mm3
newborn --6-7 million/mm3
condition;-
if count is decreased oligocythemia
eg:anemia ,malaria
if count is increased polycythemia, in the case viscosity of blood increased
erythropoiesis:-
it is the physiological formation and malnutrition of RBC
-the life span of RBC 120 days of the which they perish in liverand spleen to keep maintain the normal RBC count erythropeosis occur
in newborn it occur in all bone marrow
-in adult it occurs in bone marrow of long bone
liver take up the function within 6 month of foetal life bone starts to functioning
site:-upto 2 months -intra uterine life-yolk sac
-from third month liver is the rate for hemolysis formation of new RBC
in new born all bone marrow
in an adult -extremities all long bones
stages of erythropoiesis:-
changes that occur during erythropoiesis
1)the size of precursor cell is three time longer than RBC there for cell size decreases
2)the nucleated precursor cell is converted into non nucleated RBC
3)the precursor cell doesn't contain hemoglobin while RBC have 33% of hemoglobin
4)the precursor cell is spherical but then gets converted in to biconcave shaped RBC
5)precursor cell is basophilic while RBC is acidophilic.
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factors affecting erythropeosis:-
protein rich diet -globin sythesis
iron rich diet -heam systesis
vitamins--vit B12 folic acid -maturation factors
-recticulocytosis-immature RBC
minerals -iron ,co ,cu ,bismuth
hormones:-growth hormones,T4,testesteron
hypoxia
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