hemoglobin:-
- it ids the conjugated chromo protein present inside RBC
- MCH- 27.32 pico gram
- normal value.:-
- male 15-17gm /dl
- female -12 -15 gm /dl
- newborn-18-20 gm/dl
- STRUCTURE:-
- haem(prostetic group) 4%==ferrous+protoporphyrin
- globin(protein part 96 %===574 amino acid
- biosnysthesis:-
- starts at intermediate normablast stage
- it continue and increase at 33 % in matured RBC
- function:
- transport of o2 in the form of oxyheamoglobin
- 1 gm of heamoglobin carrying 1.34 ml of o2
- transport of co2 in the form of carbimino Hb
- buffering action.
- compounds of heamoglobin:
- oxy Hb
- carbamino Hb-= co2+ Hb
- carboxy hb=co +Hb
- glycosylated Hb=glucose+Hb
- types of Hb
- HbA-it is present in adults
- HbF- hb is in foetus -more affinity for O2
- HbS:-Hb in sickle cell anemia
- fate of Hb :-
- hemolysis
- release of Hb
- heam (ferrous separate and stored in liver)+globin(degraded into Amino acid
- protoporphyrin -converts to porphyrin converts to bilirubin(lost in urine as urinebilinogen) and biliverdin(lost in stool as stercobilies)
- jaundice_its the condition which there is an increased concentration of bile pigments
- normal value:_0.5-1.5mg/dl
- more than 2mgm/dl cause jaundice
- kernicterus-in new born jaundice due to deposition of excess of bile pigments in brain due to absence of blood brain barrier
- types of juandice:-
- haemolytic jaundice caused by hemolysis
- hepatic jaundice caused by hepatitis A,B,C
- post hepatic jaundice -there will be an obstruction in the flow of bile juice in to duodenum between gallbladder and duodenum
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